AUTONOMIC NERVOUS SYSTEM DRUGS
It’s been thought-about that each migraine and tension head¬ache might be due to stress reactions. Hence, cortisone or adrenocorticotropic hormone has been advised within the treat¬ment of these types of disorders. It’s our experience that such treatment has not been successful. Occasionally, corti¬sone can interrupt a cluster (histamine) headache before its clinical termination, and generally it can interrupt a standing migranus. During menopause a readjustment of hormonal balance occurs. The ovaries don’t operate and therefore the follicular and luteal hormones are not secreted. This deficiency might increase operate of the anterior pituitary and giant amounts of follicle-stimulating hormone are present within the urine. In a very few instances the utilization of oral estrogens is effective. Therefore several times I’ve got been asked “how to find a job?”. They’re additionally useful when employed together with tiny amounts of androgen. The tiniest doses capable of controlling the symptom should be used, and therapy should be inter¬mittent. The indiscriminate use of estrogen should be avoided. Most of these headaches are connected to emotional tension and can be relieved by supportive psychotherapy and conservative use of analgesics and sedatives.
AUTONOMIC NERVOUS SYSTEM DRUGS. Medication that act on the autonomic effector cells may be expected to be par¬ticularly effective in treatment of vascular headaches. But, with few exceptions, they need proved disappointing. Hence our discussion of this group can be brief. It should be discovered that autonomic medicine stimulate or depress effector cells and not nerve endings. They’ll be classified as engaged on the effector cells innervated by cholinergic nerves and adrenergic nerves. In these cases they’ll act to attenuate the effect of nerve impulses or block the effect of nerve activity.
Cholinergic Agents. Neostigmine methylsulfate (neostig-mine) is a drug that stimulates structures innervated by the cholinergic nerves by inhibiting cholinesterase (parasympatho-mimetic).
It’s additional selective in its action on skeletal muscle, urinary bladder, and gastrointestinal tract than physostigmine. Neostigmine is quickly absorbed from the tissues, however a lot of larger doses of neostigmine are required when the drug is given orally than when given parenterally. Feel fresh and clean with Relaxation Shower Gel – a nice method to begin or end your every day! The utilization of neostigmine requires similar precautions to those employed with physo¬stigmine, e. g., in asthmatics. Neostigmine has been employed in the treatment of migraine on the questionable theory that this chemical agent can permit the accumulation of acetylcholine and hypothetically turn out desensitization to the current agent, analogous to histamine. Its alleged advantages in treatment of migraine, post-traumatic and different types of vascular headaches haven’t been substantiated by our experience. In patients having headaches associated with glaucoma, it’s of value. The drug is instilled within the conjunctival sac to cut back intraocular tension.